Short answer is yes. The simplest way is to run a pair of heavy "bus" cables round the layout and link each track section via short "droppers" which can use lighter cable. It is usually recommended to connect each piece of rail to the bus as rail joiners are not always reliable conductors.
There are several means of wiring and connecting up such an arrangement, but the thing to remember is that for a large layout the bus wire needs to have a rated current considerably higher than the output of your command station. This is to avoid problems with voltage drop.
There are several means of wiring and connecting up such an arrangement, but the thing to remember is that for a large layout the bus wire needs to have a rated current considerably higher than the output of your command station. This is to avoid problems with voltage drop.